Risk Assessment

General Information

The Integrated Risk Information System (IRIS) is a U.S. Environmental Protection Agency (EPA) database of chemical risk values that contains information on human health effects that may result from environmental exposures. The database is maintained by EPA's National Center for Environmental Assessment.

The IRIS process consists of development of a draft Toxicological Review for the chemical, internal and external scientific reviews of the draft document, EPA responses to review comments, and development and posting on the IRIS web site of an IRIS Summary and final Toxicological Review. Highlights of the current IRIS development process include a streamlined review schedule which should result in more human health assessments being available sooner to users of the IRIS database. Opportunities occur for federal agencies to provide scientific input during an interagency review process. DoD's Chemical and Material Risk Management office coordinates DoD's scientific review and submits consolidated comments to EPA. All interagency comments are made public by EPA.

Narrative Description of EPAs Development of Toxicity Values (PDF)

U.S. EPA Flow Chart of IRIS Process (PDF)

GAO Report on IRIS process revisions (PDF)

GAO slams interagency review process that allows DoD input on science.
 

GAO testimony on revised IRIS process (PDF)

GAO testifies to how OMB facilitated interagency review slows IRIS process
 

Strategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies (PDF)

Information related to the 16 January 2007 MERIT Information Exchange Meeting.
 

CRS Report on the OMB Risk Bulletin (PDF)

CRS Report on the OMB Risk Bulletin
 

FR Notice (PDF)

EPA is soliciting public nominations for chemical substances for its 2007 agenda. EPA invites the public to submit nominations for substances to be considered for an assessment or reassessment in its IRIS Program.
 

Metals Framework (PDF)

The Framework for Metals Risk Assessment, released on March 8, 2007, outlines key principles about metals and describes how they should be considered in conducting human health and ecological risk assessments.
 

EPAs SAB Peer Review Comments (PDF)

The Framework for Metals Risk Assessment, released on March 8, 2007, outlines key principles about metals and describes how they should be considered in conducting human health and ecological risk assessments.
 

Mixtures Risk Assessment (PDF)

EPA has announced an external review of the draft document Considerations for Developing Alternative Health Risk Assessment Approaches for Addressing Multiple Chemicals, Exposures and Effects (EPA/600/R-06/013A).
 

Vision and a Strategy (PDF)

This report of the NRC Committee on Toxicity Testing and Assessment of Environmental Agents, prepared in response to EPAs request, envisions a major campaign in the scientific community to advance the science of toxicity testing.
 

Pre-Fr Notice Drinking Water Standards for Selected ECs (PDF)

In this draft notice, EPA announced its preliminary determinations for 11 contaminants listed on the second CCL. EPA had sufficient health and occurrence information to make the determination not to regulate 2,4-dinitrotoluene and 2,6-dinitrotoluene.
 

Tech Memo (PDF)

Exposure of wildlife to explosives and selected metals. Concentrations of contaminants in tissue are needed to estimate exposure of wildlife. In the absence of measured data, models are used.
 

Anal. Chem. 2007, 79, 4295-4324 (PDF)

A technical paper: Water Analysis: Emerging Contaminants and Current Issues by Dr. Susan D. Richardson National Exposure Research Laboratory, U.S. Environmental Protection Agency, Athens, Georgia 30605
 

WHO Guidelines for Drinking-Water Quality 2006 (PDF)

The addendum to the World Health Organizations (WHO) third edition of the Guidelines has been comprehensively updated to take account of developments in risk assessment and risk management since the second edition.
 

Wildlife Exposure (PDF)

Exposure of wildlife to explosives and selected metals. Concentrations of contaminants in tissue are needed to estimate exposure of wildlife. In the absence of measured data, models are used.
 

California EPA Green Chemistry Initiative Presentation (PDF)

This is a May 2007 presentation explaining the California EPAs Green Chemistry Initiative.
 

Vapor Intrusion - SERDP/ESTCP 2008 efforts (DOC)

DOD-ATL Summary IRIS Mar 05.pdf (PDF)

MERIT meeting materials 01 March 2005
 

House letter (PDF)

EC News 22 May 06
 

Toxicological Review of Tetrachloroethylene (Perchloroethylene) (External Revi (PDF)

EPA invites public comment on the draft document entitled, Toxicological Review of Tetrachloroethylene (Perchloroethylene): In Support of Summary Information on the Integrated Risk Information System (IRIS) (EPA/635/R-08/011A).

The draft tetrachloroethylene health assessment addresses both potential cancer and non-cancer human health effects that may result from chronic exposure to tetrachloroethylene. Tetrachloroethylene, commonly referred to as perc, is a solvent widely used in the dry cleaning of clothes and as a metal degreaser.
 

Meetings

ywalker slides (PPT)

Navy Environmental Health Center (NEHC) presentation to National Acad. of Sciences Committee on Improving EPA Risk Analysis - NEHC represented the three Services laboratories to the NAS committee when presenting information on DoD expertise.
 

IRIS (PPT)

ECOS/ DoD Emerging Contaminants Task Group Forum, White Paper Nov 2005
 

Other Sources of Government Data on Chemicals

Chemical Effects in Biological Systems

The CEBS database houses data of interest to environmental health scientists. CEBS is a public resource, and has received depositions of data from academic, industrial and governmental laboratories. CEBS is designed to display data in the context of biology and study design, and to permit data integration across studies for novel meta analysis.
 

PubChem

Free database of chemical structures of small organic molecules and information on their biological activities. Linked with NIH PubMed/Entrez information retrieval system.
 

ACToR

Aggregated Computational Toxicology Resource. produced by the U.S. Environmental Protection Agency, National Center for Computational Toxicology. More than 200 sources of publicly available data on environmental chemicals have been brought together and made searchable by chemical name and other identifiers, and by chemical structure. Data includes chemical structure, physico-chemical values, in vitro assay data, exposure data, and in vivo toxicology data. Chemicals include, but are not limited to, high and medium production volume industrial chemicals, pesticides (active and inert ingredients), and potential ground and drinking water contaminants.
 

Last Modified: 01 December 2010 at 16:39